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Publications

2024

  • Lejri I, Grimm A, Trempat P, Boujedaini N, Eckert A (2024) Gelsemium low doses protect against serum deprivation-induced stress on mitochondria in neuronal cells. Journal of Ethnopharmacology. doi.org/10.1016/j.jep.2024.118714

  • Varghese N, Grimm A, Cader MZ, Eckert A (2024) From Young to Old: Mimicking Neuronal Aging in Directly Converted Neurons from Young Donors. Cells. doi.org/10.3390/cells13151260

  • Fairley LH, Lai KO, Grimm A, Eckert A, Barron AM (2024) The mitochondrial Translocator protein (TSPO) in Alzheimer’s Disease: Therapeutic and Immunomodulatory Functions. Biochimie. doi.org/10.1016/j.biochi.2024.07.003

  • Fairley LH, Grimm A, Herff SA, Eckert A (2024) Translocator protein (TSPO) ligands attenuate mitophagy deficits in the SH-SY5Y cellular model of Alzheimer's disease via the autophagy adaptor P62. Biochimie. doi.org/10.1016/j.biochi.2024.01.012

  • Dinamarca MC, Colombo L, Brykczynska U, Grimm A, Fruh I, Hossain I, Gabriel D, Eckert A,  Müller M, Pecho-Vrieseling E (2024) Transmission-selective muscle pathology induced by the active propagation of mutant huntingtin across the human neuromuscular synapse. Front. Mol. Neurosci. doi.org/10.3389/fnmol.2023.1287510

PEER-REVIEWED ARTICLES

2023

  • Szabo L, Cummins N, Paganetti P, Odermatt A, Papassotiropoulos A, Karch C, Götz J, Eckert A, Grimm A (2023) ER-mitochondria contacts and cholesterol metabolism are disrupted by disease-associated tau protein. EMBO Reports, doi.org/10.15252/embr.202357499

  • Szabo L, Grimm A, Garcìa-Leòn JA, Verfaillie CM, Eckert A (2023) Genetically Engineered Triple MAPT-Mutant Human-Induced Pluripotent Stem Cells (N279K, P301L, and E10+16 Mutations) Exhibit Impairments in Mitochondrial Bioenergetics and Dynamics, Cells, doi.org/10.3390/cells12101385

  • Fairley LH, Imane L, Grimm A, Eckert A (2023) Spermidine Rescues Bioenergetic and Mitophagy Deficits Induced by Disease-Associated Tau Protein, International Journal of Molecular Sciences, doi.org/10.3390/ijms24065297

2022

  • Fairley LH, Grimm A, Eckert A (2022) Mitochondria Transfer in Brain Injury and Disease, Cells 11 (22), 3603, doi.org/10.3390/cells11223603

  • Brilkova M, Nigri M, Kumar HS, Moore J, Mantovani M, Keller C, Grimm A, Eckert A, Shcherbakov D, Akbergenov R, Seebeck P, Krämer SD, Wolfer DP, Gent TC, Böttger EC (2022) Error-prone protein synthesis recapitulates early symptoms of Alzheimer disease in aging mice. Cell Reports 40, doi.org/10.1016/j.celrep.2022.111433.

  • Lejri I, Grimm A, Trempat P, Boujedaini N, Eckert A (2022) Gelsemium Low Doses Increases Bioenergetics and Neurite Outgrowth, American Journal of BioScience. 10;4:51-60. doi: 10.11648/j.ajbio.20221002.13

  • Shcherbakov D, Nigri M, Akbergenov R, Brilkova M, Mantovani M, Isnard Petit P, Grimm A, Karol AA, Teo Y, Cortes Sanchon A, Kumar Y, Eckert A, Thiam K, Seebeck P, Wolfer DP, Böttger EC (2022) Premature aging in mice with error-prone protein synthesis. Science Advances 8, doi:10.1126/sciadv.abl9051

2021

  • Dinamarca M, Colombo L,  Brykczynska U, Grimm A, Tousiaki N,  Fruh I, Imtiaz H, Gabriel D, Eckert A, Müller M, Pecho-Vrieseling E (2021) Transmission-selective muscle pathology induced by active propagation of mutant huntingtin across the human neuromuscular synapse. Research Square, doi: 10.21203/rs.3.rs-1114693/v1

  • ​Demetrius LA, Eckert A, Grimm A (2021) Sex differences in Alzheimer’s disease: metabolic reprogramming and therapeutic intervention. Trends in Endocrinology & Metabolism, 32:963-979.

  • Moore J,Osinnii I, Grimm A, Oettinghaus B, Eckert A, Frank S, Böttger EC (2021) Silencing of the ER and Integrative Stress Responses in the Liver of Mice with Error-Prone Translation. Cells, 10 (11), 2856.

  • Grimm A (2021) Impairments in Brain Bioenergetics in Aging and Tau Pathology: A Chicken and Egg Situation? Cells, 10 (10), 2531

  • Moore J, Akbergenov R, Nigri M, Isnard-Petit P, Grimm A, Seebeck P, Restelli L, Frank S, Eckert A, Thiam K, Wolfer DP, Shcherbakov D, Böttger EC (2021) Random errors in protein synthesis activate an age-dependent program of muscle atrophy in mice. Commun Biol, 8; 4(1):703

2020

  • Szabo L, Eckert A, Grimm A (2020) Insights into Disease-Associated Tau Impact on Mitochondria. International Journal of Molecular Sciences; 21(17).

  • Varghese N, Werner S, Grimm A, Eckert A (2020) Dietary Mitophagy Enhancer: A Strategy for Healthy Brain Aging? Antioxidants; 9(10).

  • Witzig M*, Grimm A*, Schmitt K, Lejri L, Frank S, Brown SA, Eckert A (2020) Clock-Controlled Mitochondrial Dynamics Correlates with Cyclic Pregnenolone Synthesis. Cells; 9(10). *These authors contributed equally to this work.

2019

  • Lejri L, Grimm A, Eckert A (2019) Ginkgo biloba extract increases neurite outgrowth and activates the Akt/mTOR pathway. PlosOne. doi:10.1371/journal.pone.0225761

  • Grimm A*, Lejri I*, Hallé F, Abarghaz M, Schmitt M, Bourguignon JJ, Bihel F, Eckert A (2019) Mitochondria modulatory effects of new TSPO ligands in a cellular model of tauopathies. Journal of Neuroendocrinology; 32(1). doi: 10.1111/jne.12796 *These authors contributed equally to this work.

  • Lejri I*, Grimm A*, Hallé F, Abarghaz M, Klein C, Maitre M, Schmitt M, Bourguignon JJ, Mensah-Nyagan AG, Bihel F, Eckert A (2019) TSPO Ligands Boost Mitochondrial Function and Pregnenolone Synthesis. Journal of Alzheimer's Disease 72(4): 1045-58. doi: 10.3233/jad-190127 *These authors contributed equally to this work.

  • Lejri I, Agapouda A, Grimm A, Eckert A (2019) Mitochondria-and Oxidative Stress-Targeting Substances in Cognitive Decline-Related Disorders: From Molecular Mechanisms to Clinical Evidence. Oxidative Medicine and Cellular Longevity vol. 2019, Article ID 9695412, 26 pages.

  • Poirier Y, Grimm A, Schmitt K, Eckert A (2019) Link between the unfolded protein response and dysregulation of mitochondrial bioenergetics in Alzheimer’s disease. Cellular and Molecular Life Sciences 7, 1419-1431.

2018

  • Grimm A, Cummins N, Götz J (2018) Local Oxidative Damage in the Soma and Dendrites Quarantines Neuronal Mitochondria at the Site of Insult. iScience 6: 114-127

  • Lejri I, Grimm A, Eckert A (2018), Mitochondria, Estrogen and Female Brain Aging. Front. Aging Neurosci. doi:10.3389/fnagi.2018.00124.

  • Schmitt K*, Grimm A*, Dallmann R, Oettinghaus B, Restelli LM, Melissa Witzig, Ishihara N, Mihara K, Ripperger JA, Albrecht U, Frank S, Brown SA, Eckert A (2018), Circadian control of DRP1 activity regulates mitochondrial dynamics and bioenergetics. Cell Metab. doi: 10.1016/j.cmet.2018.01.011. *These authors contributed equally to this work.

2017

  • Hallé F, Lejri I, Abarghaz M, Grimm A, Klein C, Maitre M, Schmitt M, Bourguignon JJ, Mensah‐Nyagan AG, Eckert A, Bihel F (2017), Discovery of Imidazoquinazolinone Derivatives as TSPO Ligands Modulating Neurosteroidogenesis and Cellular Bioenergetics in Neuroblastoma Cells Expressing Amyloid Precursor Protein. ChemistrySelect. doi: 10.1002/slct.201701565

  • Schmitt K, Grimm A, Eckert A (2017), Amyloid-β –induced changes in molecular clock properties and cellular bioenergetics. Front Neurosci. doi: 10.3389/fnins.2017.00124.

  • Grimm A, Eckert A, Brain aging and neurodegeneration: from a mitochondrial point of view (2017). J Neurochem. doi: 10.1111/jnc.14037.

2016

  • Lejri I, Grimm A, Miesch M, Geoffroy P, Eckert A, Mensah-Nyagan AG (2016) Allopregnanolone and its analog BR 297 rescue neuronal cells from oxidative stress-induced death through bioenergetic improvement. Biochim Biophys Acta 1863:631-642.

  • Wilkaniec A, Schmitt K, Grimm A, Strosznajder JB, Eckert A (2016) Alzheimer’s amyloid-β peptide disturbs P2X7 receptor-mediated circadian oscillations of intracellular calcium. Folia Neuropathol 54 (4): 360-368.

  • Derungs R, Camici GG, Spescha RD, Welt T, Tackenberg C, Späni C, Wirth F, Grimm A, Eckert A, Nitsch RM, Kulic L (2016) Genetic ablation of the p66Shc adaptor protein reverses cognitive deficits and improves mitochondrial function in an APP transgenic mouse model of Alzheimer’s disease. Mol Psychiatry. doi:10.1038/mp.2016.112.

  • Grimm A, Mensah-Nyagan AG, Eckert A (2016) Alzheimer, mitochondria and gender. Neuroscience and biobehavioral reviews. 67:89-101.

2015

  • Grimm A, Biliouris E, Lang UE, Götz J, Mensah-Nyagan AG; Eckert A (2015) Sex hormone-related neurosteroids differentially rescue bioenergetic deficits induced by amyloid-beta or hyperphosphorylated tau protein. Cellular and molecular life sciences: CMLS 73:201-215. Impact Factor: 5.788

  • Grimm A; Friedland K, Eckert A, (2015) Mitochondrial dysfunction - the missing link between aging and sporadic AD. Biogerontology doi: 10.1007/s10522-015-9618-4.

  • Oettinghaus B, Restelli LM, Licci M, Schulz J, Savoia C, Hench J, Schmitt K, Grimm A, Morè L, Eckert A, D`Adamo P, Franken P, Handschin C, Tolnay M, Ishihara N, Mihara k, Bischofberger J, Scorrano L, Frank S (2015) Synaptic dysfunction, memory deficits and hippocampal atrophy due to ablation of mitochondrial fission in adult forebrain neurons. Cell death and differentiation 23:18-28.

2014

  • Grimm A*, Schmitt K*, Lang UE, Mensah-Nyagan AG; Eckert A (2014) Improvement of neuronal bioenergetics by neurosteroids: Implications for age-related neuro-degenerative disorders. Biochim Biophys Acta 1842:2427-2438. *These authors contributed equally to this work.

2013

2012

  • Grimm A, Lim YA, Mensah-Nyagan AG, Götz J, Eckert A (2012) Alzheimer's Disease, Oestrogen and Mitochondria: an Ambiguous Relationship. Mol Neurobiol 46(1):151-60. Impact factor: 6.190

  • Schmitt K, Grimm A, Kazmierczak A, Strosznajder JB, Götz J, Eckert A (2012) Insights into mitochondrial dysfunction: aging, amyloid-beta, and tau-A deleterious trio. Antioxid Redox Signal 16:1456-1466.

2011

  • Lim YA, Grimm A, Giese M, Mensah-Nyagan AG, Villafranca JE, Ittner LM, Eckert A, Götz J (2011) Inhibition of the mitochondrial enzyme ABAD restores the amyloid-β-mediated deregulation of estradiol. PLoS One 6:e28887.

BOOK CHAPTERS

​

  • Eckert A, Grimm A, Müller W.E (2022) Antidementia Medications: Pharmacology and Biochemistry. In: Riederer P., Laux G., Nagatsu T., Le W., Riederer C. (eds) NeuroPsychopharmacotherapy. Springer, Cham. https://doi.org/10.1007/978-3-319-56015-1_192-1

  • Grimm A, Schmitt K, Eckert A, Advanced mitochondrial respiration assay for evaluation of mitochondrial dysfunction in Alzheimer’s disease, Systems Biology of Alzheimer’s Disease: Methods and Protocols, edited by Walker JM (2016), Humana Press, Springer publishing group 1303:171-183. Impact Factor: 1.29

  • Grimm A, Mensah-Nyagan AG, Eckert A, Neurosteroids in oxidative stress-mediated injury in Alzheimer disease, Oxidative stress in vertebrates and invertebrates: molecular aspects on cell signaling, edited by Farooqui T, Farooqui AA (2012), Hoboken, N.J.: John Wiley & Sons.

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